We examined a new formulation of lipid nanoparticles designed to deliver TNF-α siRNA, which has previously shown effectiveness in battling rheumatoid arthritis. These nanoparticles, made from lecithin and cholesterol, effectively encapsulated siRNA and demonstrated minimal release, targeting inflamed tissues well.
In mouse models, particularly those unresponsive to methotrexate, this formulation successfully reduced inflammation and bone damage. This underscores its potential as a promising treatment for patients struggling with rheumatoid arthritis who don't benefit from traditional therapies.
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Most Useful Reviews
9
Helpful for memory
541 people found this helpful
Lecithin comprises phospholipids and essential fatty acids. Symptoms of its deficiency include memory disorders and poor attention. It is sourced from soy, sunflower, and egg. I am truly pleased that it has helped me. Be healthy!
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9
Solving health problems
382 people found this helpful
I've noticed improved thinking since I ordered it to address specific health issues related to my autoimmune disorder. Following the instructions, I managed to give up bad habits without difficulty.
Read More
9
Child behaviour improvement
182 people found this helpful
Super-lecithin works wonders for my child! Since using it, he has become less irritable, with improved attention and memory—making learning enjoyable. Lecithin protects the gastrointestinal tract, crucial for a healthy baby. After two months of sunflower lecithin for my hyperactive son, I've noticed clear educational improvements; he is calmer and easier to manage. By the way, my four-year-old confidently chews the capsules! If you’ve found my review helpful, please click YES.
We examined a new formulation of lipid nanoparticles designed to deliver TNF-α siRNA, which has previously shown effectiveness in battling rheumatoid arthritis. These nanoparticles, made from lecithin and cholesterol, effectively encapsulated siRNA and demonstrated minimal release, targeting inflamed tissues well.
In mouse models, particularly those unresponsive to methotrexate, this formulation successfully reduced inflammation and bone damage. This underscores its potential as a promising treatment for patients struggling with rheumatoid arthritis who don't benefit from traditional therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 51 Reviews
8.3
All Reviews
Positive Reviews
Negative Reviews
9
Helpful for memory
541 people found this helpful
Lecithin comprises phospholipids and essential fatty acids. Symptoms of its deficiency include memory disorders and poor attention. It is sourced from soy, sunflower, and egg. I am truly pleased that it has helped me. Be healthy!
Read More
9
Solving health problems
382 people found this helpful
I've noticed improved thinking since I ordered it to address specific health issues related to my autoimmune disorder. Following the instructions, I managed to give up bad habits without difficulty.
Read More
9
Child behaviour improvement
182 people found this helpful
Super-lecithin works wonders for my child! Since using it, he has become less irritable, with improved attention and memory—making learning enjoyable. Lecithin protects the gastrointestinal tract, crucial for a healthy baby. After two months of sunflower lecithin for my hyperactive son, I've noticed clear educational improvements; he is calmer and easier to manage. By the way, my four-year-old confidently chews the capsules! If you’ve found my review helpful, please click YES.
Read More
9
Improved energy levels
61 people found this helpful
Sunflower lecithin is an indispensable dietary supplement for me due to Gilbert's syndrome. Its quality is superb. My child and I have endured this condition for years without realising that such a supplement could alleviate our symptoms. The benefits are tremendous, especially when combined with other liver detox preparations, resulting in a noticeable surge of energy and the eradication of persistent fatigue. Duodenal soundings further enhance one’s well-being, leading to clarity of thought. The capsules are large, but I can swallow them with meals without difficulty. I highly recommend purchasing it. If beneficial, thumbs up!
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9
Allergy relief achieved
8 people found this helpful
I'm very pleased with this lecithin! The most remarkable result was my daughter taking it alongside Ester-C, resulting in a three-week improvement for her cold allergy. She can now enjoy winter activities outdoors without issues. However, I noticed that ordering two smaller jars from this manufacturer is more cost-effective than one large jar.
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Lecithin is a natural substance that is found in various plant and animal tissues, primarily derived from soybeans, eggs, or sunflower seeds. It is a phospholipid, which means it contains both a hydrophilic (water-attracting) and hydrophobic (water-repellent) component. This unique structure makes lecithin an excellent emulsifier, which allows it to blend ingredients that typically don't mix well together, such as oil and water. As a result, it is commonly used in food products, cosmetics, and nutritional supplements to improve texture, stability, and shelf life.
In food products, lecithin can be found in a wide range of items, from chocolates to baked goods, providing a smoother mouthfeel and enhancing flavor distribution. Additionally, lecithin plays a role in promoting better absorption of certain nutrients in the body, which has led to its popularity as a dietary supplement. While lecithin is generally considered safe for consumption, those with soy allergies should opt for alternatives like sunflower lecithin. Whether you're a home cook looking to improve your dishes or someone interested in the potential health benefits, understanding lecithin's versatile uses can enhance your culinary and nutritional knowledge.
Based on user reviews, the timeline for seeing results from lecithin supplementation for autoimmune disorders can vary significantly. Many users report improvements within a few weeks of consistent use. For instance, one user noted noticeable cognitive enhancement after just two weeks of taking sunflower lecithin Read Review. Another user experienced a significant memory improvement in their child within just a week Read Review.
However, other users have indicated that it may take longer for benefits to manifest, with some reporting improvements after a two-month period Read Review. It's important to consider that individual experiences may vary based on dietary habits, the severity of symptoms, and personal health conditions. Ultimately, users recommend maintaining a consistent intake for optimal results.
This supplement shows promise for individuals with autoimmune disorders, particularly rheumatoid arthritis. Research on innovative lipid nanoparticles designed to deliver TNF-α siRNA indicates that this formulation can effectively target inflammation. In studies conducted on mouse models, specifically those unresponsive to methotrexate, the nanoparticles reduced inflammation and prevented bone damage, highlighting their potential to serve as an alternative treatment for those who do not respond to conventional therapies [1].
While this research supports the efficacy of lipid nanoparticles in managing rheumatoid arthritis, it is essential to note that further studies are required to validate these findings in humans and to understand the broader implications for various autoimmune disorders. Therefore, while encouraging, the current evidence suggests that more comprehensive investigations are needed before firmly establishing this supplement as a reliable treatment option for all autoimmune conditions.
Based on user reviews, many individuals have reported significant improvements in various symptoms after incorporating lecithin into their daily routine. A notable number of users mentioned enhanced cognitive function, with one 72-year-old observing marked improvements in memory and cognition within just two weeks of taking sunflower lecithin Read Review. Additionally, parents have shared positive outcomes for their children, including better attention and memory—one mother noted a drastic reduction in her child's irritability after two months, resulting in improved learning experiences Read Review.
Users have also expressed benefits beyond cognitive enhancements, citing physical health improvements such as increased energy levels and alleviated liver discomfort. For instance, one user remarked on achieving normal bilirubin levels after supplementing with lecithin, while another experienced significant relief from skin issues like psoriasis Read Review. However, individual results can vary widely based on personal health contexts and consistent use, so it's essential to manage expectations and consult healthcare professionals as needed.
Based on user reviews, many individuals with autoimmune disorders have reported positive experiences when combining lecithin with other supplements. For instance, one user noted significant improvements in their condition when they began taking lecithin alongside Ester-C, leading to enhanced relief from cold allergies for their daughter Read Review. Similarly, another user shared their success in combining lecithin with NAC, which resulted in skin improvements and a noticeable increase in overall well-being Read Review.
In general, users advocate for the benefits of sunflower lecithin as a safer option compared to soy lecithin, which some believe can exacerbate autoimmune symptoms Read Review. Many have highlighted that when used in conjunction with liver detox preparations, the results have been particularly pronounced, yielding significant improvements in energy levels and general health Read Review. While personal experiences vary widely, it appears that a thoughtful combination of lecithin with other supportive supplements could enhance the management of various autoimmune conditions.
Based on user reviews, many individuals have reported varying doses of Lecithin, especially sunflower Lecithin, as an effective supplement for managing autoimmune disorders. A notable trend among the reviews indicates that users find significant improvement in cognitive function and general health after taking Lecithin consistently. For instance, one user mentioned experiencing improved thinking related to their autoimmune issues, highlighting that following the recommended dosage contributed to their success in overcoming certain health challenges (Read Review). Others noted that the product helped alleviate symptoms linked to Gilbert's syndrome and supported liver health, suggesting its positive impact on autoimmune-related complications (Read Review).
While specific doses weren't always detailed, several users indicated that they took one or two capsules daily to reap the benefits, such as boosted cognitive function and clearer thinking. One reviewer remarked on the additional positive experiences of family members using the supplement, emphasizing its continued integration into their health regimen (Read Review). The consistency in usage and preference for sunflower-based products appear to be a recurring theme, suggesting a tailored approach to those with autoimmune conditions should consider the source and dosage of Lecithin for optimal results.
9
Notable improvement
3 people found this helpful
I am 72, and since taking the sunflower lecithin, my cognition and memory have significantly improved. I noticed a difference within two weeks. iHerb's service is professional; I order all my vitamins from them, and they are shipped quickly and reliably.
9
Memory enhancement observed
15 people found this helpful
Lecithin was recommended due to attention distraction for my son. Thankfully, I discovered that this type is suitable for boys! Once it arrived, I noticed the capsules were large, but my child happily takes all sorts of vitamins. Within a week, his memory improved significantly, making it much easier for him to learn poems, which previously was a challenge.
9
Child behaviour improvement
182 people found this helpful
Super-lecithin works wonders for my child! Since using it, he has become less irritable, with improved attention and memory—making learning enjoyable. Lecithin protects the gastrointestinal tract, crucial for a healthy baby. After two months of sunflower lecithin for my hyperactive son, I've noticed clear educational improvements; he is calmer and easier to manage. By the way, my four-year-old confidently chews the capsules! If you’ve found my review helpful, please click YES.
7.5
Normal bilirubin levels
5 people found this helpful
This wonderful lecithin has proven effective; my bilirubin levels are normal now. My husband started taking it too. Initially, he experienced bitterness, as I did, but that passed. It alleviated liver discomfort; while this may be coincidental, I will continue to purchase it and highly recommend trying it.
9
Allergy relief achieved
8 people found this helpful
I'm very pleased with this lecithin! The most remarkable result was my daughter taking it alongside Ester-C, resulting in a three-week improvement for her cold allergy. She can now enjoy winter activities outdoors without issues. However, I noticed that ordering two smaller jars from this manufacturer is more cost-effective than one large jar.
9
Restorative liver function
4 people found this helpful
I’m a huge fan of lecithin! It’s incredibly beneficial, particularly for the liver and brain health. Cleansing the liver is essential for good health, and it can be restored completely. I currently combine it with NAC and am pleased with the results — my skin has cleared up! Hence, I suggest you buy it; you won’t regret the decision!
7.5
Liver restoration
2 people found this helpful
This is the best lecithin! A major advantage is that it comes from sunflower instead of soy, which causes inflammation for those with autoimmune disorders like mine (autoimmune thyroiditis). The large capsules are easy to swallow, and I take it regularly to support liver health and improve bile function. I'm committed to continuous use.
9
Improved energy levels
61 people found this helpful
Sunflower lecithin is an indispensable dietary supplement for me due to Gilbert's syndrome. Its quality is superb. My child and I have endured this condition for years without realising that such a supplement could alleviate our symptoms. The benefits are tremendous, especially when combined with other liver detox preparations, resulting in a noticeable surge of energy and the eradication of persistent fatigue. Duodenal soundings further enhance one’s well-being, leading to clarity of thought. The capsules are large, but I can swallow them with meals without difficulty. I highly recommend purchasing it. If beneficial, thumbs up!
9
Solving health problems
382 people found this helpful
I've noticed improved thinking since I ordered it to address specific health issues related to my autoimmune disorder. Following the instructions, I managed to give up bad habits without difficulty.
7.5
Liver support
4 people found this helpful
I prefer sunflower lecithin, as soy is not recommended for those with autoimmune conditions. It's an excellent support for liver health. The large jar is perfect for my family, ensuring we have an adequate supply.
9
Novel siRNA treatment for arthritis
Lipid nanoparticles with minimum burst release of TNF-α siRNA show strong activity against rheumatoid arthritis unresponsive to methotrexate.
We examined a new formulation of lipid nanoparticles designed to deliver TNF-α siRNA, which has previously shown effectiveness in battling rheumatoid arthritis. These nanoparticles, made from lecithin and cholesterol, effectively encapsulated siRNA and demonstrated minimal release, targeting inflamed tissues well.
In mouse models, particularly those unresponsive to methotrexate, this formulation successfully reduced inflammation and bone damage. This underscores its potential as a promising treatment for patients struggling with rheumatoid arthritis who don't benefit from traditional therapies.
References
Aldayel AM, O'Mary HL, Valdes SA, Li X, Thakkar SG, et al. Lipid nanoparticles with minimum burst release of TNF-α siRNA show strong activity against rheumatoid arthritis unresponsive to methotrexate. J Control Release. 2018;283:280. doi:10.1016/j.jconrel.2018.05.035